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Breakthrough: Stem Cell Technology Can Cure Blindness Caused By Macular Degeneration
In a breakthrough procedure, British surgeons have successfully used stem cells to restore the vision of two aging patients suffering from macular degeneration, a condition responsible for half the cases of blindness all over the world.
The results of the first ever clinical trial of this procedure was recently published in the journal Nature Biotechnology and has the potential to revolutionize the way vision is restored around the world.
What Is Macular Degeneration?
Macular degeneration is an age-related tissue degeneration of the retinal pigment epithelium that is present right behind the rods and cones of the retina.
When healthy, the retinal pigment epithelium is responsible for transporting nutrients and removing waste material produced by the surrounding cells. So when this layer starts to degenerate due to age (generally after 50), it loses its ability to clear out waste matter, which slowly destroys all the surrounding cells of the retina.
This leads to the formation of a blind spot in the macula of the eye, which is the most-sensitive part of the retina, thus causing partial blindness where the peripheral vision is spared but the central vision is destroyed.
A person suffering from macular degeneration cannot read, drive, or recognize people's faces.
How Do You Treat Macular Degeneration?
There are many treatment options available to people suffering from this disease, but all of them only aim to stall its progression. Until now.
The novel stem-cell-based repair surgery was given the green signal for clinical trial a year ago, which allowed the researchers to implant a 4 x 6 mm stem-cell patch into the retinas of two patients. These cells were coated with a synthetic compound to enable them to remain in place but continue dividing into the specialized cells of the retinal pigment epithelium.
The patients were followed up with over the next 12 months to study the behavior of the stem-cell implant. The results were:
Some
of
the
cells
were
rejected
by
the
body,
but
overall,
the
implant
functioned
relatively
well.
The
patients
recovered
their
failing
vision,
even
if
it
was
not
as
sharp
as
their
vision
used
to
be
before
the
degenerative
disease
set
in.
Other Areas Where Stem Cells Have Made Massive Breakthroughs
Stem-cell technology has been picking up steam for quite some time now. The following are other areas where stem cells have made massive breakthroughs:
In
2007,
Dr
Shinya
Yamanaka
at
Kyoto
University
discovered
that
human
skin
cells
had
the
potential
to
be
converted
into
heart
stem
cells.
This
allowed
researchers
at
the
Massachusetts
General
Hospital
and
Harvard
Medical
Hospital
to
create
a
beating
human
heart
out
of
skin
cells
in
2016,
which
is
the
closest
we
have
come
to
synthesizing
organs
fit
for
transplantation.
Earlier
in
2017,
researchers
at
the
Universities
of
Bristol,
Cambridge,
and
Oxford
successfully
created
synthetic,
immune-silent
blood
out
of
stem
cells.
Named
ErythroMer,
the
synthetic
blood
is
currently
going
through
human
trials.
Scientists
can
now
grow
"mini
brains" in
labs
out
of
stem
cells.
These
organoids
resemble
actual
human
brains
and
are
currently
being
used
to
study
neurological
diseases
and
fully
study
this
mystery
organ.
The Future Is Here!
Scientific breakthroughs and discoveries are occurring at an exponential pace at present. So you can definitely expect even more awe-inducing revelations to happen by the end of 2018.
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