Click it and Unblock the Notifications
Latest Updates
-
How To Design A Work From Home Office That Boosts Focus And Creativity -
Skincare Hacks 101: The Truth About Clear Skin Most People Miss While Following Viral Beauty Trends -
Bhindi Masala Recipe: Your Guide to Dry Sabzi Perfect Technique -
From Manesar to Seattle: Indian Sculptor Naresh Kumar Kumawat Creates Swami Vivekananda Monument In The US -
World Liver Day 2026: What Your Waistline Could Be Telling You About Your Liver -
Delhi Style Soft Dahi Bhalla Recipe: A Taste of Tradition -
Food And Medicine Combinations: Common Mistakes That Reduce Effectiveness Without You Realising -
If You Have PCOS, Summer Might Be Affecting You More Than You Think -
Akshaya Tritiya 2026: What to Buy and Avoid for Good Luck, According to Rinhee Suberwal -
Akshaya Tritiya 2026: 6 Trendy Gold Jewellery Designs You’ll Wear Beyond The Festive Day
High Cholesterol Can Cause Bone Loss
According to a research, high cholesterol level might lead to bone loss and severe heart problems. Read this article to know about the details.
High cholesterol, which is a known factor for the decrease in heart health may harm more than our cardiovascular systems and lead to bone loss, say researchers including one of Indian-origin.
The new research conducted using animal models suggests that high levels of cholesterol can trigger mitochondrial oxidative stress on cartilage cells -- connective tissue -- causing them to die.
This may ultimately lead to the development of osteoarthritis -- a type of arthritis that occurs when flexible tissue at the ends of bones wears down, said Indira Prasadam, a researcher at Queensland University of Technology in Brisbane, Australia.
For the study, Prasadam and her team used two different animal models to mimic human hypercholesterolemia.
The first was a mouse model that had an altered gene called Apolipoprotein E that made the animals hypercholesteremic.
The other was a rat model, and the animals were fed a high-cholesterol diet, causing diet-induced hypercholesterolemia.
Both models were fed a high-cholesterol diet or control normal diet, after which they underwent a surgery that mimics knee injuries in people and was designed to bring on osteoarthritis.
Both the mice and the rats that were subjected to surgery and fed with high-cholesterol diets showed more severe osteoarthritis development than seen in the normal diet group.
However, when both the mice and the rats were exposed to the cholesterol-lowering drug atorvastatin and mitochondrion-targeted antioxidants, the development of osteoarthritis was markedly decreased in relation to the untreated groups.
This study tested the potential therapeutic role of mitochondria targeting antioxidants in high-cholesterol-induced osteoarthritis, the researchers said.
"Our team has already begun working alongside dieticians to try to educate the public about healthy eating and how to keep cholesterol levels at a manageable level that won't damage joints," Prasadam said.
The research was published online in The FASEB Journal.
Inputs From IANS
Continue with Google