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Unknown Organ Under Human Skin Found, May Help Detect Pain
A
recent
study
published
in
the
journal
Science,
'Specialized
cutaneous
Schwann
cells
initiate
pain
sensation'
asserts
the
discovery
of
a
previously
unknown
organ,
located
under
the
skin.
The
unknown
organ
is
said
to
possess
the
ability
to
help
you
feel
pain
from
pricks
(small
amount).
It
was
thought
that
a
small
amount
of
pain
or
pain
from
a
pinprick
was
perceived
through
the
nerve
endings
located
below
the
outer
layer
of
the
skin.
But
the
new
study
disregards
this
by
suggesting
that
it
is
not
only
the
nerves
but
also
the
cells
that
are
tangled
up
in
cells
that
cause
you
to
flinch
when
something
pricks
you
[1]
.
Although science speaks of the various kinds of sensory organs in the skin, those were the ones involved in touch sensation. The newfound sensory organ is a mesh of branched cells and nerves, responds to the external cues and passes on the information to your brain and stands apart from the already known sensory organs because this one plays a significant role in pain reception [2] .
The sensory organ is sensitive to pricks or jabs and sends the signal to the brain on the application of pressure, which then is sent back to the site of the prick, which causes the sensation of pain.
The cells that compose the sensory organ, which is termed as Schwann cells, "look a little bit like an octopus, with long, tentacle-like protrusions extending into surrounding nerves", said Patrik Ernfors, a Professor of Tissue Biology at the Karolinska Institute in Sweden.
In order to assimilate the function of these specific Schwann cells in the skin [3] , the researchers conducted a lab study using the method optogenetics. The study helped in gathering the result that the cells were able to help perceive the sensation of pain.
Genetically Engineered Human Miniature Livers To Help Test Medicines & Study Diseases
Speaking about the lab study, the researcher has said, "When we turn these cells off, the animals feel much less pressure and pain". The Schwann cells are being considered as a new potential target cell for medication.
Now, the researchers are gearing to examine whether the cell has any role in creating the sensation of chronic pain [1] .
"Chronic pain has become a focus of attention as opioid addiction continues to debilitate lives and cause mortality", asserted the researchers [4] .
- [1] Abdo, H., Calvo-Enrique, L., Lopez, J. M., Song, J., Zhang, M. D., Usoskin, D., ... & Ernfors, P. (2019). Specialized cutaneous Schwann cells initiate pain sensation. Science, 365(6454), 695-699.
- [2] Doan, R. A., & Monk, K. R. (2019). Glia in the skin activate pain responses. Science, 365(6454), 641-642.
- [3] Hartlehnert, M., Derksen, A., Hagenacker, T., Kindermann, D., Schäfers, M., Pawlak, M., ... & zu Horste, G. M. (2017). Schwann cells promote post-traumatic nerve inflammation and neuropathic pain through MHC class II. Scientific reports, 7(1), 12518.
- [4] Saplakoglu, Y. (2019, August 19). Scientists Just Found a Previously Unknown Organ Lurking Under Your Skin, and It Helps Detect Pain. Retrieved from, https://www.livescience.com/new-skin-organ.html
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