Just In
- 3 hrs ago Summer Fashion: Your Bollywood Style White Outfits Guide To Keep It Cool And Chic
- 5 hrs ago Sonam Kapoor Stuns In A Huisang Zhang Skirt Set, A Skirt-Top Style Guide From The OG Fashionista!
- 8 hrs ago Thrissur Pooram 2024: Date, Time, History, Significance, And Celebrations Related To Kerala's Rich Traditions
- 12 hrs ago Daily Horoscope, 19 April 2024: Gemini Will Have A Controversial Day In Terms Of Love
Don't Miss
- Finance Emmforce Autotech IPO Debut April 23: Issue Size, Price Band, Check Details?
- Education NLSIU Announces the Rajiv K. Luthra Foundation Grant
- Technology Dell Introduces AI-Powered Laptops and Mobile Workstations for Enterprises in India
- News Electoral Bonds Controversy: Amit Shah Slams Rahul Gandhi, Asks Opposition Too Got Money, Is It Extortion?
- Movies Main Ladega, Mary Kom, Toofan - 5 Bollywood Boxing Dramas You Need To Watch
- Sports T20 World Cup: 'He will definitely be in my list' - Anjum Chopra handpicks 2 wicketkeeper-batters for India squad
- Automobiles Tata Motors To Manufacture Jaguar Land Rover Cars In Billion Dollar TN Plant - Report
- Travel Journey From Delhi To Ooty: Top Transport Options And Attractions
Study Reveals A New Drug May Help Treat Brain Tumours
The research team led by Dr Richard Hill at the Brain Tumour Research Centre at University of Portsmouth (in collaboration with the University of Algarve (Portugal), the University of Liverpool (UK) and Innovate Pharmaceuticals) examined the possible impact of IP1867B in treating a brain tumour, which kills thousands of people every year.
IP1867B, the potential brain cancer treatment drug may help in shrinking brain tumours. The research study was conducted by applying the drug to existing (cancer) treatments and IP1867B was effective in boosting the potency of the treatments and renewed sensitivity to some treatments.
Artificial Intelligence Can Help Decode Epileptic Brains, Affirms Research
IP1867B can be termed as a revolutionary finding considering the limited success rates of cancer treatments. The limitation of the treatments is due to several factors such as the tumour's ability to develop resistance and hide from the treatment, lack of clinical effectiveness of the treatment, severe side effects and the inability of the medicine to penetrate through the blood-brain barrier. Consequently, during the study, IP1867B was successful at bypassing such factors [1] .
In the study, 'IP1867B suppresses the insulin-like growth factor 1 receptor (IGF1R)...adult high-grade gliomas' published in the journal of Cancer Letters suggested that IP1867B - a combination of aspirin, triacetin and saccharin, worked towards reducing the size of adult high-grade glioma brain tumours in a mouse model. Along with that, the drug also helped in reducing the gastrointestinal tract problems caused due to the consumption of conventional aspirin tablets.
Therefore, the researchers asserted that IP1867B could be effective against one of the most aggressive forms of human brain cancer, glioblastoma (GBM). According to Dr Hill, the researcher team head, "To produce a completely new drug takes many years and is very expensive. By focusing our efforts on testing novel formulation techniques, we can move closer to treatment more quickly than would otherwise be possible."
He continued, "We will continue to urgently investigate which drugs will combine most effectively and safely with IP1867B, to improve these results even further and reduce the need for long-term use. There is still much work to be done, but many reasons to be excited about future studies."
The researcher tested various combinations of drugs to understand the most effective treatment, which also included separately testing the three key components of IP1867B. It was found that IP1867B was more effective than some of the chemotherapeutics being used in treatments[2] .
The drug, IP1867B reduced the action of Epidermal Growth Factor Receptor (EGFR) and blocked the Insulin-like Growth Factor 1 pathway. This, in turn, helped reduce the tumour's ability to acquire resistance to the EGFR inhibitors. IP1867B can affect multiple targets, which in turn helps in highlighting the tumour and reverse acquired resistance [3] .
Medication To Suppress HIV Infection Discovered, Researchers Assert
Dr James Stuart, Medical Director at Innovate Pharmaceuticals asserted, "The next step is to take IP1867B into 'first in human' trial. Innovate are actively driving this next stage of development."
- [1] Mihajluk, K., Simms, C., Reay, M., Madureira, P. A., Howarth, A., Murray, P., ... & Hill, R. (2019). IP1867B suppresses the insulin-like growth factor 1 receptor (IGF1R) ablating epidermal growth factor receptor inhibitor resistance in adult high grade gliomas.Cancer letters,458, 29-38.
- [2] EurekAlert. (2019, August 05). Shrinking brain tumours and opening the door for targeted cancer therapies. Retrieved from https://www.eurekalert.org/pub_releases/2019-08/uop-sbt080519.php
- [3] Thomas, N. A., Abraham, R. G., Dedi, B., & Krucher, N. A. (2019). Targeting retinoblastoma protein phosphorylation in combination with EGFR inhibition in pancreatic cancer cells.International journal of oncology,54(2), 527-536.
- healthWorld Brain Tumour Day: Can Phone Use Cause Brain Tumour?
- healthWorld Brain Tumour Day 2023: 5 Best Foods To Reduce Risk
- pregnancy parentingWorld Brain Tumour Day: Is It Common For Kids To Get Brain Tumour? What Are The Signs?
- healthWorld Brain Tumour Day: What Are The Risk Factors For Brain Tumour?
- disorders cureExpert Article: 7 Warning Signs Of Brain Tumour To Be Aware Of
- disorders cureWorld Brain Tumour Day: Know The Types, Causes, Symptoms, Risk Factors, Diagnosis And Treatment
- kidsNow, Special Mobiles For Kids!
- insyncEvan's Dream With Hot Havana Nights
- wellness10 Serious Pain Symptoms
- healthExclusive: Cervical Cancer In India, Doctor Shares Preacautions And Treatments That One Needs To Be Aware Of
- healthTV Actor Dolly Sohi Passes Away Due To Cervical Cancer, Know The Early Signs That Are Beyond Early Detection
- healthGhazal Maestro Pankaj Udhas Passes Away Due To Pancreatic Cancer, Know Risk Factors, Prevention, Treatments