Just In
- 3 hrs ago Daily Horoscope, 29 March 2024: Gemini Businessmen Should Be Careful, Leo May Not Feel Well Today
- 8 hrs ago Aditi Rao Hydari's 8 Tips for Glowing Skin: A Celebrity Skincare Routine Unveiled, Bonus Tips Included!
- 8 hrs ago April 2024 Health Horoscope: Know How This Month Will Affect Zodiac Signs In Terms Of Wellness
- 9 hrs ago Good Friday 2024: Wishes, Messages, Greetings, Texts, Images, Quotes, WhatsApp, And FB Status
Don't Miss
- Sports IPL 2024 Most Runs: Top 10 run-scorers in contention of Orange Cap after Riyan Parag blitz in RR vs DC Match
- News Mukhtar Ansari Death News: Family Alleges Poisoning In Jail; BSP Supremo Mayawati Demands Inquiry
- Movies Hot Spot X Review: Kalaiyarasan Harikrishnan Starrer Promises To Be A Delightfully Engaging Movie
- Technology PUBG Mobile to Get 120fps Support With Next Update
- Automobiles Explore Top Alternatives To KTM 125 Duke For Motorcycle Enthusiasts In India
- Finance 1:10 Split: Tata's Gems & Jewellery Stock Rises 54,103% In Longest Run; Motilal Says Buy For Rs 4,300 TP
- Education RSMSSB Junior Instructor Recruitment 2024; Apply online for 2500 Posts, Check out for more details
- Travel Explore Tamil Nadu's Diverse Wedding Venues
Sperm Cells Created From Ear Tissue May Treat Male Infertility
Read to know about the latest method to treat make infertility.
Scientists have created sperm cells from small pieces of ear tissue to help genetically infertile male mice produce healthy offspring, an advance that may pave the way for novel therapies to treat human infertility. Our sex is determined by the X and Y chromosomes, researchers said. Usually, females have two X chromosomes (XX) and males have one X and one Y (XY), but about one in 500 men are born with an extra X or Y. Having three rather than two sex chromosomes can disrupt formation of mature sperm and cause infertility.
In a study published in the journal Science, researchers at the Francis Crick Institute in the UK have found a way to remove the extra sex chromosome to produce fertile offspring. If the findings can be safely transferred into humans, it might eventually be possible for men with Klinefelter syndrome (XXY) or Double Y syndrome (XYY) that are infertile to have children through assisted reproduction using this technique. The team took small pieces of ear tissue from XXY and XYY mice, cultured them and collected connective tissue cells known as fibroblasts. They turned the fibroblasts into stem cells and noticed that in the process, some of the cells lost the extra sex chromosome. With an existing method, they used specific chemical signals to 'guide' the stem cells into becoming cells that have the potential to become sperm.
These cells developed into mature sperm when injected into the testes of a host mouse. The researchers then harvested these mature sperm and used them through assisted reproduction to create healthy, fertile offspring. "Our approach allowed us to create offspring from sterile XXY and XYY mice," said Takayuki Hirota from the Francis Crick Institute.
"It would be interesting to see whether the same approach could one day be used as a fertility treatment for men with three sex chromosomes," said Hirota. In a preliminary experiment, the team found that stem cells produced from fibroblasts of men with Klinefelter syndrome also lost the extra sex chromosome.
"There is currently no way to make mature sperm outside of the body. In our mouse experiments we have to inject cells that have the potential to become sperm back into the testes to help them finish developing," said James Turner, Group Leader at the Francis Crick Institute. "But we found that this caused tumours in some of the mouse recipients.
So reducing the risk of tumour formation or discovering a way to produce mature sperm in a test tube will have to be developed before we can even consider this in humans," said Turner.
- healthNew Study Finds Links Infertility In Men With Increased Risk Of Cancer For Them And Their Relatives
- pregnancy parentingWhat Age Should You Get Tested For Infertility?
- pregnancy parentingUnlocking IVF Success: Factors That Contribute To IVF Success
- pregnancy parentingWorld IVF Day: Debunking Myths About In Vitro Fertilization
- basicsWorld Fertility Day: The Decline of Fertility Rate In India: What Does It Mean?
- basicsWhat Is Subfecundity In Couples? Causes, Symptoms, Risk Factors, Treatments And Management
- basics15 Potential Medical And Non-Medical Reasons Why You Are Not Getting Pregnant
- disorders cureExpert Speaks About Male Infertility And Why It Shouldn't Be Ignored
- wellnessClinico-Psycho-Social Aspects Of Infertility
- disorders cureOrchitis (Inflammation Of The Testicles): Causes, Symptoms, Risk Factors And Treatments
- basicsHow To Boost Your Sperm Count Naturally
- nutrition12 Lesser Known Health Benefits Of Royal Jelly