Just In
- 29 min ago Amitabh Bachchan's Youthful Avatar In Kalki 2898 AD Is Impressive, Check Actors Who Sported Digital De-Aging!
- 39 min ago Full Moon In Scorpio In April 2024: How It Will Affect 12 Zodiac Signs
- 1 hr ago Why You Should Soak Mangoes In Water Before Consuming Them, This Small Step Comes With Big Rewards!
- 1 hr ago Add These 18 Foods To Your Daily Diet To Increase Your Sperm Count And Boost Male Fertility
Don't Miss
- Sports IPL 2024: No Place For Sanju Samson in Irfan Pathan's 15-Member Indian T20 World Cup Squad
- Movies Arti & Dipak Sangeet: Bride-To-Be Turns Up Emotions As She Dedicates Song To Krushna Abhishek, Watch Video
- News ByteDance To Sell TikTok Or Face Ban In US: Senate Passes Bill
- Automobiles Kia Carens Earns Mixed Safety Ratings Amidst Growing Popularity In India
- Finance Okay Play India Posts 12.79% Revenue Growth In Q4 After 1:10 Stock Split Approval
- Education Karnataka SSLC Class 10 Result, Tentative Date, How and Where to Check KSEAB Result 2024
- Travel Fly in Luxury: 10 Ways to Get Free Flight Upgrades
- Technology Realme Narzo 70 & Narzo 70x Launching Today in India: Check Price, Specs, Live Stream Details
Whipple Disease: Causes, Symptoms, Diagnosis & Treatment
A rare bacterial infection, which most often affects your joints and digestive system, Whipple disease impairs the breakdown of foods and hampers the body's ability to absorb nutrients [1] . It can also affect other organs such as the heart, brain and eyes. If proper treatment is not received, it can turn fatal. Timely medical intervention is therefore essential.
About 40 per cent of people with this illness show neurological symptoms such as abnormalities of the eye and facial muscle movements, dementia, seizures, memory loss, weakness and headaches [2] .
Read on to know how this rare infectious disease can cause multiple infections in different organs and its treatment possibilities.
What Is Whipple Disease?
Being a multi-system infectious bacterial disease, Whipple disease interferes with the body's ability to metabolize fats. It is caused by the bacterium Tropheryma whipplei [3] . This illness is named after George Whipple, who discovered the bacteria causing this disease in 1907. Although it can affect the heart, joints, brain, eyes and lungs, it usually tends to occur in the gastrointestinal system.
It has been found that this illness is more common in men and also the neurological symptoms are found to be more common in individuals who have severe abdominal disease. This ailment can be treated with antibiotics, but sometimes patients might relapse and need long-term treatment. 87 per cent of people with Whipple disease are men aged between 40 and 60 years [4] .
Symptoms Of Whipple Disease
Although the symptoms vary widely among patients, the most common signs of this disease are as follows [5] :
- Weight loss - usually happens due to malabsorption
- Weakness
- Stomach pain
- Anaemia
- Fatigue
- Darkening of the skin exposed to the sun
Sometimes endocarditis is the only symptom of Whipple disease. There can be severe breathlessness and swelling of the legs due to fluid build-up. The heart becomes inflamed and the body is unable to pump fluids through the body.
The following signs occur when Whipple disease progresses to the central nervous system [6] :
- Insomnia
- Dementia
- Facial numbness
- Vision problems
- Hearing loss
- Memory problems
- Loss of mobility
Causes Of Whipple Disease
As mentioned, Whipple disease is caused by a type of bacterium called Tropheryma whipplei. This bacterium is said to affect the mucosal lining of the small intestine followed by the formation of small lesions within the intestinal wall [7] . This illness also damages the villi that line the small intestine. Research is still underway as to how the bacteria originates or how it spreads to humans.
Few researchers say that the people who develop this disease have a genetic defect in their immune system response, which makes them more prone to becoming sick when exposed to this bacteria. However, Whipple disease is not very common. It affects about only 1 in 1 million people [8] .
It has been found that this condition is more common in farmers and people who work outdoors, especially the ones who have frequent contact with soil and sewage waste water. It is worth noting that this disease is not transmitted from person to person.
Diagnosis Of Whipple Disease
Several tests and exams may be conducted to diagnose this illness. These include [9] the following.
- Blood tests
- Upper GI endoscopy and enteroscopy
- Physical examination
- Medical and family history
At times, on seeing the results, your general healthcare practitioner might refer you to a gastroenterologist. The chances of the following common conditions with almost similar symptoms are ideally first eliminated, before beginning the treatment procedure [10] :
- Coeliac disease
- Inflammatory rheumatic disease
- Neurologic disease
- Intra-abdominal lymphoma
- Mycobacterium avium complex (an infection that affects people with AIDS)
In some cases, a biopsy might be conducted to reach a conclusive decision about the diagnosis of Whipple disease. A tissue sample is collected from the lining of the small intestine [11] . The tissue is examined under a microscope for the presence of disease-causing bacteria and their lesions.
Treatment For Whipple Disease
The ideal treatment methodology followed is with the use of antibiotics to destroy the bacteria causing the infection. The treatment is long-term and usually lasts for a year or two [12] . The people who have not suffered any brain or nervous system complications usually recover completely after a full course of antibiotics.
In case a person relapses during treatment, the antibiotics might need to be altered as the patient might have developed a resistance to the drugs [13] . Doctors prefer prescribing antibiotics that not just wipe out infections of the intestinal tract but also cross a layer of tissue around the brain. This is to eliminate bacteria that might have entered the brain and central nervous system.
The ideal treatment plan for Whipple disease is with the use of intravenous ceftriaxone or penicillin [14] for the first two to four weeks. This can be followed by a long-term oral antibiotic course of sulfamethoxazole-trimethoprim. The symptoms should improve within one to two weeks of starting the antibiotic treatment.
As Whipple disease causes nutrient-absorption difficulties, your doctor might recommend taking vitamin and mineral supplements to ensure adequate nutrition in the body.
Complications Of Whipple Disease
Usually, complications arise due to malnutrition (which happens when the villi in the small intestine are damaged). Damage to the villi impairs nutrient absorption [15] . Nutritional deficiencies are highly common in people with Whipple disease and hence causes extreme fatigue, weakness, joint pain and weight loss.
If not treated on time, Whipple disease falls under the category of being a progressively fatal disease. In spite of being rare, several associated deaths have been reported. The deaths are usually due to late diagnosis and delayed treatment. The primary cause of death is the spread of the infection to the central nervous system. This is an irreversible damage.
- [1] Dutly, F., & Altwegg, M. (2001). Whipple's disease and "Tropheryma whippelii".Clinical microbiology reviews,14(3), 561-583.
- [2] Marumganti, A. R., & Murphy, T. F. (2008). Whipple's disease: neurological relapse presenting as headache for two years.Journal of general internal medicine,23(12), 2131-2133.
- [3] Marth, T. (2015). Systematic review: Whipple's disease (Tropheryma whipplei infection) and its unmasking by tumour necrosis factor inhibitors.Alimentary pharmacology & therapeutics,41(8), 709-724.
- [4] Bureš, J., Kopáčová, M., Douda, T., Bártová, J., Tomš, J., Rejchrt, S., & Tachecí, I. (2013). Whipple's Disease: Our Own Experience and Review of the Literature.Gastroenterology research and practice,2013, 478349.
- [5] Durand, D. V., Lecomte, C., Cathébras, P., Rousset, H., & Godeau, P. (1997). Whipple disease. Clinical review of 52 cases. The SNFMI Research Group on Whipple Disease. Societe Nationale Francaise de Medecine Interne.Medicine,76(3), 170-184.
- [6] Compain, C., Sacre, K., Puéchal, X., Klein, I., Vital-Durand, D., Houeto, J. L., … Papo, T. (2013). Central nervous system involvement in Whipple disease: clinical study of 18 patients and long-term follow-up.Medicine,92(6), 324-330.
- [7] Schneider, T., Moos, V., Loddenkemper, C., Marth, T., Fenollar, F., & Raoult, D. (2008). Whipple's disease: new aspects of pathogenesis and treatment.The Lancet infectious diseases,8(3), 179-190.
- [8] Chandra, S. R., Raj, P., Pai, A. R., & Reddy, N. (2018). A Case of Whipple's Disease: A Very Rare Cause for Rapidly Progressive Dementia.Indian journal of psychological medicine,40(3), 280-283.
- [9] Günther, U., Moos, V., Offenmüller, G., Oelkers, G., Heise, W., Moter, A., … Schneider, T. (2015). Gastrointestinal diagnosis of classical Whipple disease: clinical, endoscopic, and histopathologic features in 191 patients.Medicine,94(15), e714.
- [10] Conly, J. M., & Johnston, B. L. (2001). Rare but not so rare: The evolving spectrum of Whipple's disease.The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses,12(3), 133-135.
- [11] Obst, W., von Arnim, U., & Malfertheiner, P. (2014). Whipple's Disease.Viszeralmedizin,30(3), 167-172.
- [12] Dutly, F., & Altwegg, M. (2001). Whipple's disease and "Tropheryma whippelii".Clinical microbiology reviews,14(3), 561-583.
- [13] Keinath, R. D., Merrell, D. E., Vlietstra, R., & Dobbins III, W. O. (1985). Antibiotic treatment and relapse in Whipple's disease: long-term follow-up of 88 patients.Gastroenterology,88(6), 1867-1873.
- [14] Bureš, J., Kopáčová, M., Douda, T., Bártová, J., Tomš, J., Rejchrt, S., & Tachecí, I. (2013). Whipple's Disease: Our Own Experience and Review of the Literature.Gastroenterology research and practice,2013, 478349.
- [15] Zubiaga, L., Ruiz-Tovar, J., Castro, M. J., Ortiz-de-Solózano, F. J., Luque-de-León, E., Jiménez, J. M., & Carbajo, M. A. (2019). Whipple disease after bariatric surgery: from malabsorption to malnutrition status.Nutrición hospitalaria: Organo oficial de la Sociedad española de nutrición parenteral y enteral,36(1), 238-241.
- nutritionWorld TB Day 2022: Foods To Consume And Avoid By Tuberculosis Patients
- disorders cureWhat Are The Common Diseases Caused By Bacteria In Humans?
- disorders cureWhat Is Strep Throat? Causes, Symptoms, Complications, Treatments And Prevention
- healthGovernment Launches 'One Health' Consortium For Surveillance Of Bacterial, Viral Infections
- wellnessWorld Milk Day 2021: Evidence-Based Health Benefits Of Donkey Milk
- wellnessHow To Get Rid Of A Stye: Safe And Effective Home Remedies
- disorders cureStye (Lump On The Eyelid): Causes, Symptoms, Risk Factors, Complication, Treatments And Prevention
- wellnessWhat Is Walking Pneumonia? Is It A Serious Condition?
- disorders cureCapnocytophaga canimorsus Infection: Causes, Symptoms, Risk Factors And Treatment
- disorders cure11 Best Home Remedies To Treat Cellulitis
- disorders curePneumonia: Causes, Symptoms, Risk Factors, Diagnosis, Treatment And Prevention
- disorders cureMeningitis: Types, Causes, Symptoms, Risk Factors, Complications, Prevention And Treatment