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Gene That Causes Enlarged Hearts Identified
Researchers from the Medical Research Council's Clinical Sciences Centre and the National Heart and Lung Institute at Imperial College, London, have found that genetics play a vital role in explaining why some people develop an enlarged heart, a condition that can cause a heart attack.
Reasons like strenuous exercise, high blood pressure and obesity might attribute to develop irregular heart growth, but scientists have for the first time linked enlarged hearts with a gene, osteoglycin (Ogn) – a finding they claim would help in developing new treatments for the condition.
The scientists carried out their study on rodents and some 30 humans, reports BBC.
They found that Ogn regulated the growth of the heart's main pumping chamber, its left ventricle and thus played an important role in heart function. The heart can become enlarged if this gene behaves abnormally, and thus puts the person at an increased risk of common heart diseases and heart attacks.
Enlarged hearts are usually found in people who are obese, have diabetes or high blood pressure. However, it can even occur in elite athletes who don"t have even one of the mentioned problems. That"s what was diagnosed in the post-mortem of Cameroon football midfielder Marc-Vivien Foe, who died in 2003 after collapsing during an international match in France.
The researchers pointed out that the only treatment option available in today"s date was lowering the blood pressure and this discovery could lead to new and more effective ways of treating people
"But, now that we are unravelling how genes control heart growth, we can gain a better understanding of common forms of heart disease. This could lead to new and more effective ways of treating people," said Dr Stuart Cook, one of the study authors.
The genetic link to enlarged hearts has earlier been found through a work at University College, London, suggesting that genes involved in metabolism may also be linked to the condition.
"When
a
person's
heart
is
continually
struggling
to
meet
demand
-
for
example
following
damage
by
a
heart
attack
-
it
may
enlarge,
lose
its
elasticity
and
not
pump
efficiently.
These
researchers
have
used
highly
advanced
technology
to
discover
a
new
gene
-
osteoglycin
-
that
is
important
in
controlling
heart
growth
in
these
conditions.
Osteoglycin
is
now
a
potential
target
to
aim
for
with
future
therapies,"
said
associate
medical
director
Professor
Jeremy
Pearson.
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