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Childhood Cancer Treatment May Affect Short-Term Memory
Children exposed to cancer treatment such as chemotherapy are likely to have decreased cognitive flexibility and a weaker short-term memory, researchers say.
Children exposed to cancer treatment such as chemotherapy are likely to have decreased cognitive flexibility and a weaker short-term memory, researchers say.
The results show that cognitive functions which are slow developing or mature during adolescence -- in particular short-term memory -- are very vulnerable to the chemotherapy treatment.
However, cognitive functions such as long-term memory and the ability to concentrate remain largely unaffected as they develop before the treatment.
"Tests that require quick switching between tasks or remembering new information for a short amount of time were clearly more difficult for former cancer patients. The developmental stage of the brain at the start of the cancer treatment probably plays a decisive role," Rudi D'Hooge, Professor at the University of Leuven in Belgium.
For the study, the team examined 31 young adults who underwent chemotherapy as a child, on average around the age of six and a half.
The survivors' performance was compared on a number of psychological tests with the results of a control group.
Further, analysing phosphorylated Tau (p-Tau) -- a protein which is part of the internal structure of our nerve cells -- the researchers found that high concentrations of p-Tau predict cognitive problems at a later age.
"If
we
systematically
measure
these
p-Tau
levels
in
the
future,
we
can
offer
specific
help
to
children
with
high
values.
With
early
coaching
aimed
at
the
most
relevant
functions
we
can
prevent
problems
that
would
otherwise
manifest
10
to
15
years
after
the
treatment," Iris
Elens,
a
psychiatrist
at
the
University
of
Leuven.
With
Inputs
From
IANS
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