Just In
- 1 hr ago Mahavir Jayanti 2024: Date, Time, History, Celebrations And Teachings Of Lord Mahavir In Jainism
- 2 hrs ago Parineeti Chopra Saree Looks: Check Amar Singh Chamkila Actor's Regal Fashion Statements
- 4 hrs ago Vidya Balan's 'Do Aur Do Pyaar' Urban Boho Style Avatar Is Relatable And Inspiring, Check Her Modern Avatar!
- 12 hrs ago Golden Rules To Follow For Happy Marriage For A Long Lasting Relationship
Don't Miss
- Sports Manchester City vs Chelsea, FA Cup: Preview, Team News, Predicted Lineup, H2H
- News Neha Hiremath Murder Case: Accused Fayaz's Father Apologises, Says Give My Son The Most Severe Punishment
- Finance Portfolio Management Services PMS vs. Mutual Funds: Detail Analysis
- Movies Metro In Dino: When Ananya Panday Warns Sara Ali Khan Not To Touch Aditya Roy Kapur As She Pairs Up With Him
- Technology Garena Free Fire Max Redeem Codes for April 20, 2024: Get Access to the Latest In-game Loot
- Automobiles Ford Mustang 60th Anniversary Package – Limited To Just 1,965 Units
- Education Exam Pressure Does Not Exist; Studying Punctually is Crucial; Says Aditi, the PSEB 2024 Topper
- Travel Journey From Delhi To Ooty: Top Transport Options And Attractions
Vulvar Cancer: Types, Symptoms, Causes And Treatment
Vulvar cancer is also termed as vulval cancer. It is a comparatively rare type of cancer that grows on the female external genitals. The vulva is the area of skin surrounding the urethra and vagina, including the clitoris and labia. It consists of the inner and outer lips of the vagina, the clitoris, and the opening of the vagina, and glands near the vaginal opening. The cancer mostly appears on the outer vaginal lips and accounts for around 0.6 per cent of all cancers in women [1] .
However, the cancer can affect other parts of the vulva as well, especially when it begins to spread. The cancer develops at a slow pace, initially beginning as vulvar intraepithelial neoplasia by affecting the healthy skin cells around the vulva. It causes a lump or sore on the vulva that causes itching and is mostly diagnosed in older women [2] .
Vulvar cancers can be easily diagnosed and immediate medical attention in its early stages can help cure the cancer. A lack of treatment can result in the abnormal cells turning into malignant cancer [3] .
Types Of Vulvar Cancer
The disease is categorised into five major categories [4] .
1. Squamous cell carcinoma
It is the most common type of vulvar cancer and affects the skin cell first. About 90 per cent of vulvar cancers are squamous cell carcinoma. It affects the flat, outer layers of skin and the symptoms take several years to be noticeable. Some cases of squamous cell carcinoma have been linked to the human papillomavirus (HPV), which is found mostly in younger women [5] .
2. Vulvar melanoma
About 10 per cent of the vulvar cancers are reported to be vulvar melanoma. It develops as a dark patch, like discolouration in the skin and is the second most common type of vulvar cancer. It is mostly reported in Caucasian women aged between 50-80 years. It can also affect young women and are distinguished into three types, superficial spreading, nodular, and acral lentiginous melanoma. Melanoma has a high risk of spreading to other parts of the body [6] .
3. Sarcoma
It starts in the bone, connective tissue cells or the bones. Sarcomas are mostly malignant and can develop at any age (even childhood)[7] .
4. Verrucous carcinoma
This type is a subtype of squamous cell cancer. It appears in the form of a wart and gradually develops with time[8] .
5. Adenocarcinoma
It develops in the glandular tissue and accounts for a very small proportion of the vulvar cancers[7] .
Symptoms Of Vulvar Cancer
The initial sign indicating the onset of the cancer is a lump that causes itching, irritation, or bleeding [9] .
The most common symptoms of the cancer are as follows [10] :
- Wart-like growths
- Abnormal vaginal bleeding or tenderness
- Pain and burning
- Painful sexual intercourse
- Painful urination
- Persistent itching in the vulvar area
- Rawness and sensitivity
- Dark discolouration in cases of melanoma
- Ulceration
- Thickened skin
Causes Of Vulvar Cancer
Usually, cancer develops when the body is not able to control cell growth. The mutations in the DNA cause the cell to grow and divide rapidly. These cells form a cancerous tumour that can spread to the other parts of the body[11] .
The cancer can spread in the event of two things, when a cancerous cell manages to move through the body using the blood or lymph systems, destroying the healthy tissue. It can also be caused when a cancerous cell manages to move through the body using the blood or lymph systems, destroying the healthy tissue [12] .
Risk Factors Of Vulvar Cancer
Although there is uncertainty over the exact cause behind cancer, the following factors can increase the chance of developing vulvar cancer [13] [14] [15] .
Age: More than half of the women who have been diagnosed with vulvar cancer are aged above 70 years.
Vulvar intraepithelial neoplasia (VIN): It is a sort of precancerous state where certain cells within the vulvar epithelium have low levels of carcinoma. Women with VIN have a higher chance of developing vulvar cancer.
Human papillomavirus (HPV): Women infected with HPV are increasingly prone to developing vulvar cancer.
The other major risk factors pertaining to the development of vulvar cancer are as follows [16] :
- Having a skin condition that can affect the vulva, such as lichen planus
- Melanoma
- Sexually transmitted infections (STIs)
- Smoking
- Kidney transplant
- Human immunodeficiency virus (HIV)
- Systemic lupus erythematosus
- Psoriasis
- Radiotherapy
- Weak immune system
- Having a history of precancerous conditions of the vulva
- Having a history of genital warts
Diagnosis Of Vulvar Cancer
In order to understand the extent of your condition, the doctor will begin by checking your overall health. He/she will examine your daily habits, lifestyle, and medical history. Then, the doctor will examine your vulva for the possibilities of lumps or anything unusual [17] .
A colposcopy will be conducted using a special magnifying device to examine your vulva. The magnifying glass will help determine the possible growth of any abnormalities.
A cystoscopy will be conducted where your bladder will be examined so as to determine whether cancer has spread to that area.
A proctoscopy will be carried out where your rectum will be examined so as to check whether cancer has spread to the rectal wall.
The diagnosis may also involve imaging scans which will help the doctor in determining whether cancer has spread, and if so, where to. An MRI scan or a CT scan will be used. An X-ray may also be used so as to check whether cancer has reached the lungs [18] [19] .
Staging Of Vulvar Cancer
If the diagnosis and the following biopsy confirms the presence of vulvar cancer, with the help of the imaging scans the doctor will stage cancer. It helps the doctor in classifying the severity of cancer and thereby aid in developing a suitable treatment plan for you [20] .
The location of the primary tumour, the spread of cancer to nearby lymph nodes, and the size and number of tumours are the factors that impact the staging.
Vulvar cancer is staged from 0 to 4 and higher the stage, severe the condition [18] [21] .
Stage 0: It refers to very early cancer, which is confined to the surface of the skin of the vulva.
Stage 1: The cancer is limited to the vulva or perineum (area of skin between the vaginal opening and anus). Its size goes up to 2 centimetres.
Stage 2: The cancer has spread from the vulva to nearby structures. And has affected the lower portions of the urethra, vagina, and anus.
Stage 3: The cancer has spread to the lymph nodes.
Stage 4A: The cancer has extensively spread to the lymph nodes and to the upper portions of the urethra. The bladder, rectum, or pelvic bone are affected at this point.
Stage 4B: The cancer has spread to the distant organs and lymph nodes.
Treatments For Vulvar Cancer
The stage and severity of the cancer determine the treatment plan. The four main treatment methods used in the event of vulvar cancer are mentioned below [22] [23] .
1. Surgery
It is the primary treatment method adopted for treating vulvar cancer. It helps in removing the cancer without causing any problems in one's sexual function. In the initial stages, limited surgery will help get rid of the tumour. However in the later stages when the cancer has spread to nearby organs, such as the urethra or rectum, extensive surgeries are required [23] .
The surgeries involved are as follows:
Laser
surgery,
where
the
laser
beam
is
used
as
a
knife
to
remove
the
lesions.
Excision,
where
the
surgeon
attempts
to
remove
all
the
cancer
and
surrounding
tissues.
Skinning
vulvectomy,
where
the
surgeon
removes
the
top
layer
of
skin
with
the
cancer.
Radical
vulvectomy,
where
the
surgeon
removes
the
whole
vulva
(including
the
clitoris,
vaginal
lips,
the
opening
to
the
vagina,
and
the
nearby
lymph
nodes).
2. Radiation therapy
This will aid in shrinking the deep lesions or tumours before surgery, making it easier to remove it. It makes use of high-powered energy beams, such as X-rays and protons, to kill the cancer cells. It also helps in relieving the symptoms and improving the quality of life.
3. Chemotherapy
The aggressive form of chemical drug therapy aids in slowing down the growth of the cancer cells, it also stops the spreading of the cells. Chemotherapy is applied when the cancer is more advanced and has spread to other organs in the body. It is often combined with radiation therapy to shrink large vulvar cancers.
4. Biologic therapy
It is a form of immunotherapy and uses synthetic or natural substances to help the body fight against the cancer [24] .
Prevention Of Vulvar Cancer
You can reduce your risk of developing the condition by following the below-mentioned points [25] .
- Practising safe sex
- Limiting your number of sexual partners
- Having the HPV vaccination
- Attending scheduled cervical smear tests
- Not smoking
- [1] Levenback, C., Burke, T. W., Gershenson, D. M., Morris, M., Malpica, A., & Ross, M. I. (1994). Intraoperative lymphatic mapping for vulvar cancer. Obstetrics and gynecology, 84(2), 163-167.
- [2] Sturgeon, S. R., Brinton, L. A., Devesa, S. S., & Kurman, R. J. (1992). In situ and invasive vulvar cancer incidence trends (1973 to 1987). American journal of obstetrics and gynecology, 166(5), 1482-1485
- [3] De Cicco, C., Sideri, M., Bartolomei, M., Grana, C., Cremonesi, M., Fiorenza, M., ... & Paganelli, G. (2000). Sentinel node biopsy in early vulvar cancer. British journal of cancer, 82(2), 295.
- [4] Smith, J. S., Backes, D. M., Hoots, B. E., Kurman, R. J., & Pimenta, J. M. (2009). Human papillomavirus type-distribution in vulvar and vaginal cancers and their associated precursors. Obstetrics & Gynecology, 113(4), 917-924.
- [5] Hampl, M., Sarajuuri, H., Wentzensen, N., Bender, H. G., & Kueppers, V. (2006). Effect of human papillomavirus vaccines on vulvar, vaginal, and anal intraepithelial lesions and vulvar cancer. Obstetrics & Gynecology, 108(6), 1361-1368.
- [6] Canavan, T. P., & Cohen, D. (2002). Vulvar cancer. American family physician, 66(7), 1269-1274.
- [7] Insinga, R. P., Liaw, K. L., Johnson, L. G., & Madeleine, M. M. (2008). A systematic review of the prevalence and attribution of human papillomavirus types among cervical, vaginal, and vulvar precancers and cancers in the United States. Cancer Epidemiology and Prevention Biomarkers, 17(7), 1611-1622.
- [8] Sturgeon, S. R., Brinton, L. A., Devesa, S. S., & Kurman, R. J. (1992). In situ and invasive vulvar cancer incidence trends (1973 to 1987). American journal of obstetrics and gynecology, 166(5), 1482-1485.
- [9] Alkatout, I., Schubert, M., Garbrecht, N., Weigel, M. T., Jonat, W., Mundhenke, C., & Guenther, V. (2015). Vulvar cancer: epidemiology, clinical presentation, and management options. International journal of women's health, 7, 305.
- [10] Eaton, A. A., Baser, R. E., Seidel, B., Stabile, C., Canty, J. P., Goldfrank, D. J., & Carter, J. (2017). Validation of clinical tools for vaginal and vulvar symptom assessment in cancer patients and survivors. The journal of sexual medicine, 14(1), 144-151.
- [11] Höckel, M., Trott, S., Dornhöfer, N., Horn, L. C., Hentschel, B., & Wolf, B. (2018). Vulvar field resection based on ontogenetic cancer field theory for surgical treatment of vulvar carcinoma: a single-centre, single-group, prospective trial. The Lancet Oncology, 19(4), 537-548.
- [12] Hinten, F., Molijn, A., Eckhardt, L., Massuger, L. F., Quint, W., Bult, P., ... & de Hullu, J. A. (2017). VULVAR CANCER: TWO PATHWAyS WITH DIFFERENT LOCALIZATION AND PROGNOSIS. PDF hosted at the Radboud Repository of the Radboud University Nijmegen, 39.
- [13] Satmary, W., Holschneider, C. H., Brunette, L. L., & Natarajan, S. (2018). Vulvar intraepithelial neoplasia: risk factors for recurrence. Gynecologic oncology, 148(1), 126-131.
- [14] Muigai, J., Jacob, L., Dinas, K., Kostev, K., & Kalder, M. (2018). Potential delay in the diagnosis of vulvar cancer and associated risk factors in women treated in German gynecological practices. Oncotarget, 9(9), 8725.
- [15] Carlson, J. W., Kauderer, J., Hutson, A., Carter, J., Armer, J. A., Lockwood, S., ... & Bonebrake, A. J. (2018). GOG 244, the lymphedema and gynecologic cancer (LEG) study: Incidence and risk factors in newly diagnosed patients. Gynecologic Oncology, 149, 6-7.
- [16] Nooij, L. S., Brand, F. A. M., Gaarenstroom, K. N., Creutzberg, C. L., de Hullu, J. A., & van Poelgeest, M. I. E. (2016). Risk factors and treatment for recurrent vulvar squamous cell carcinoma. Critical reviews in oncology/hematology, 106, 1-13.
- [17] Koh, W. J., Greer, B. E., Abu-Rustum, N. R., Campos, S. M., Cho, K. R., Chon, H. S., ... & Dorigo, O. (2017). Vulvar cancer, version 1.2017, NCCN clinical practice guidelines in oncology. Journal of the National Comprehensive Cancer Network, 15(1), 92-120.
- [18] Halec, G., Alemany, L., Quiros, B., Clavero, O., Höfler, D., Alejo, M., ... & de Sanjose, S. (2017). Biological relevance of human papillomaviruses in vulvar cancer. Modern Pathology, 30(4), 549.
- [19] Hinten, F., Molijn, A., Eckhardt, L., Massuger, L. F. A. G., Quint, W., Bult, P., ... & de Hullu, J. A. (2018). Vulvar cancer: Two pathways with different localization and prognosis. Gynecologic oncology, 149(2), 310-317.
- [20] Guglielmo, P., Crivellaro, C., Elisei, F., Montanelli, L., Guerra, L., & Landoni, C. (2017). 18F-FDG PET/CT in preoperative staging of vulvar cancer patients: is it really effective?. Journal of Nuclear Medicine, 58(supplement 1), 352-352.
- [21] Hagemann, I. S., Cole, L. L., Cosin, J. A., Gress, D. M., Mutch, D. G., & Olawaiye, A. B. (2018). Controversies in Gynecologic Cancer Staging: An AJCC Cancer Staging Manual, Perspective. Ajsp: Reviews & Reports, 23(3), 118-128.
- [22] te Grootenhuis, N. C., Van der Zee, A. G. J., Van Doorn, H. C., Van Der Velden, J., Vergote, I., Zanagnolo, V., ... & Slangen, B. F. M. (2016). Sentinel nodes in vulvar cancer: long-term follow-up of the GROningen INternational Study on Sentinel nodes in Vulvar cancer (GROINSS-V) I. Gynecologic oncology, 140(1), 8-14.
- [23] Oonk, M. H., Planchamp, F., Baldwin, P., Bidzinski, M., Brännström, M., Landoni, F., ... & Querleu, D. (2017). European Society of Gynaecological Oncology guidelines for the management of patients with vulvar cancer. International Journal of Gynecological Cancer, 27(4), 832-837.
- [24] Mahner, S., Prieske, K., Grimm, D., Trillsch, F., Prieske, S., von Amsberg, G., ... & Woelber, L. (2015). Systemic treatment of vulvar cancer. Expert review of anticancer therapy, 15(6), 629-637.
- [25] Bailey, H. H., Chuang, L. T., DuPont, N. C., Eng, C., Foxhall, L. E., Merrill, J. K., ... & Blanke, C. D. (2016). American Society of Clinical Oncology statement: human papillomavirus vaccination for cancer prevention. Journal of Clinical Oncology, 34(15), 1803-1812.
- healthExclusive: Cervical Cancer In India, Doctor Shares Preacautions And Treatments That One Needs To Be Aware Of
- healthTV Actor Dolly Sohi Passes Away Due To Cervical Cancer, Know The Early Signs That Are Beyond Early Detection
- healthGhazal Maestro Pankaj Udhas Passes Away Due To Pancreatic Cancer, Know Risk Factors, Prevention, Treatments
- healthNew Study Finds Links Infertility In Men With Increased Risk Of Cancer For Them And Their Relatives
- healthIs Pancreatic Cancer Curable? Know The Causes, Warning Signs, And Treatment Of This Uncommon Silent Killer
- insyncBaba Vanga's Prophecy For 2024 May Come True With New Vaccine In Russia For Cancer
- healthDetecting Bowel Cancer: 10 Signs Of This Silent Killer To Watch Out For And Seek Medical Attention
- health10 Cancer Fighting Foods That Help That Play Significant Role In Supporting Body's Natural Defences
- healthWorld Cancer Day 2024: 5 Simple Daily Habits To Reduce The Risk Of Developing Cancer
- healthWorld Cancer Day 2024: Messages, Greetings, Wishes, Texts, Images, FB And WhatsApp Status
- healthExclusive: Poonam Pandey Didn't Die Of Cancer, However, It Does Spark Urgency For Cervical Cancer Awareness
- healthErotica Star Poonam Pandey 'Dead From Cervical Cancer' Stunt: Causes, Symptoms, Treatment Of Cervical Cancer