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Kids Crucial Part Of Tuberculosis Control Efforts
Including kids in the evaluation of tuberculosis treatment is crucial, according to a new study.
William Burman from the Denver Public Health and the University of Colorado Health Sciences Center, Denver, USA, and colleagues said that kids are an often ignored but important part of tuberculosis control efforts.
In high-burden settings, children make up as much as 20 percent of new cases of active tuberculosis.
Young children are also at high risk of having severe, rapidly progressive forms of tuberculosis.
However, nearly 40 years after the development of short-course treatments in adults, there are still major uncertainties about dosing for children of common TB drugs.
"Only
in
recent
years
has
there
been
a
substantial
effort
to
manufacture
child-friendly
formulations
of
first-line
tuberculosis
drugs
(such
as
crushable
mini-pills,
granules,
oral
suspensions)," the
researchers
said.
"And in the past 15 years, children have been included in only one study of new agents for tuberculosis: a large Phase 3 trial evaluating once-weekly rifapentine + isoniazid for treatment of latent tuberculosis," they added.
The researchers said that including children in drug development is especially critical, as the two main threats to tuberculosis control, HIV-related immunodeficiency and drug-resistant tuberculosis, challenge our ability to develop effective drug regimens.
Burman and colleagues outline several traditional barriers to the involvement of children in tuberculosis drug development such as difficulty confirming TB diagnosis, concern about side effects, and regulatory requirements.
However, they also describe how these barriers can be overcome, arguing that researchers, regulatory agencies, advocates, and government agencies and private foundations that fund drug development must insist that the development pathways for all new treatments include specific plans for when and how children will be involved.
"Children
have
the
same
right
to
benefit
from
research
as
do
adults.
While
this
lack
of
involvement
may
be
understandable
in
the
short-term,
it
is
not
acceptable
in
the
long-term,"
the
researchers
said.
The
study
is
published
in
this
week's
PLoS
Medicine.
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