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Meftal-Spas Tablet: Why Govt Has Issued Safety Alert Against This Popular Painkiller For Menstrual Cramps
Meftal Spas is an anti-inflammatory and non-steroidal drug manufactured by Blue Cross Laboratories Pvt. Ltd. It is available in tablet form and cannot be bought over the counter without a bona fide prescription. Meftal Spas composition includes two active salts namely dicyclomine hydrochloride and mefenamic acid in 1:25 ratio.
Meftal, a painkiller popularly used to treat menstrual cramps, has come under the radar as the Indian Pharmacopoeia Commission (IPC) has issued a drug safety alert for Mefenamic acid. The IPC has urged consumers and healthcare professionals to remain vigilant regarding potential adverse drug reactions (ADRs) linked to the drug.
The alert stems from a preliminary analysis of adverse drug reactions reported in the Pharmacovigilance Programme of India (PvPI) database, revealing instances of Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome.
DRESS Syndrome
DRESS syndrome, a severe allergic reaction affecting approximately 10% of individuals, poses potential life-threatening risks and is associated with specific medications. It comes as fever, skin rash, lymphadenopathy, hematological abnormalities, and internal organ involvement, typically surfacing two to eight weeks after the drug has been taken.
Side Effects
Studies suggest a correlation between the use of nonsteroidal anti-inflammatory drugs (NSAIDs), including mefenamic acid, and an increased risk of cardiovascular events, particularly in individuals with pre-existing heart conditions.
In addition to the intended effects, consumption of meftal spas may also cause side effects in some people . These side effects end once the course of treatment is completed. However, if any symptoms are observed, immediate medical attention should be obtained. The following side effects can be observed:
Abdominal pain
Indigestion
Dry mouth
Blurred vision
Increased blood pressure
Swelling and skin rash, for example, Urticaria and Edema
Acidity and Gastritis
Vomiting and nausea
Itching and increased sweating
Precaution:
Pregnancy- Meftal Spas should not be taken during pregnancy as it can cause abnormalities in the growing foetus. It can also delay labor and can increase bleeding tendency in both mother and child.
Kidney disease- In patients with kidney disease, this tablet should be used with caution. Tablet dosage can need to be adjusted. Patients with end-stage kidney disease should avoid taking this tablet.
Liver- Meftal is also not appropriate for liver patients and should be taken as per doctor's advice.
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