- 1 hr ago Madhuri Dixit-Nene Skincare Routine: Besan Face Pack For A Quick Refresher; DIY In 5 Steps!
- 1 hr ago Eid 2022: Deepika Padukone To Sara Ali Khan, Your Ethnic Outfit Guide From B-Town Beauties
- 2 hrs ago New WHO Initiative Aims To Stop The Spread Of Malaria Vectors: What You Should Know
- 3 hrs ago Eating Refined Grains Such As White Rice May Increase Premature Heart Disease Risk
- Finance ICICI Securities Bets On This Maharatna Stock For Return Up To 38%, Target Time 1 Year
- News Deaths of Indian prisoners in Pakistani jails 'alarming': MEA
- Education Mrs. Rupal Dalal, MD, JD Institute of Fashion and Technology conferred with the Global Gandhi Award
- Movies Mumfluencers Awards 2022: Josh Hosts A Happening Event In Collaboration With Grehalakshmi Magazine
- Technology Crypto Thieves Exploit Blockchain Bridges to Snatch $100Mn From Binance-linked network
- Sports FIFA Under-17 Women's World Cup: India eye a quarterfinal berth, says coach Dennerby
- Automobiles Hero Vida V1 Plus & V1 Pro Electric Scooters Launched In India - Prices Start At Rs 1.45 Lakh
- Travel Great Pyramid of Giza: The Only Standing Structure from The Seven Wonders of The Ancient World
The ICMR's top tuberculosis research institute NIRT is in the process of developing and validating sputum-free tests using blood, stool, urine and saliva samples for diagnosing the disease.
Sputum is a thick mucus found in the respiratory tract, typically as a result of infection.Director of ICMR's National Institute for Research in Tuberculosis (NIRT) Dr Padmapriyadarsini C said accurate, fast non-sputum-based tests for the detection of tuberculosis are urgently needed to close the diagnostic gap.
"In conditions where you do not have sputum for tests such as in children, elderly, or in the case of extra-pulmonary TB where sputum is not very helpful, any other sample -- stool, urine, blood or saliva may be used for diagnosing TB," she told PTI.
Obtaining sputum specimens for testing is particularly difficult in children. With them being the least likely to be diagnosed, they are most at risk of severe disease, Dr Padmapriyadarsini said.
Tuberculosis is diagnosed by detecting the bacteria in the sputum. But in blood-based biomarker discovery scientists are looking at how the TB bacteria affects the host's immune system, Dr Subash Babu, an NIH scientist and scientific director of ICER-India told PTI.
The ICER in collaboration with the NIRT is doing the research in this matter."We are in the process of developing blood-based biomarkers that will provide the basis for accurate diagnostic tests for TB in children and predict treatment outcome," Dr Babu said.
In adults, blood-based biomarkers may be also useful for identifying those at risk of TB treatment failure or recurrence of the disease, he said.
Blood biomarkers may help detect extra-pulmonary tuberculosis which affects other parts of the body such as lymph nodes, bones, brain or kidneys.
"We have published a number of research articles in high-quality scientific journals about the identification of host molecules which can aid in the diagnosis of pulmonary and extra-pulmonary TB in children and adults, as well as for predicting treatment failure or recurrence in adults before they begin anti-TB treatment," Dr Babu said.
It is estimated that of the total tuberculosis patients in India, around 6 per cent are children. Diagnosing TB among the paediatric population is a challenge due to low bacterial load and the inability of children to expectorate sputum.
Also, there are no practical gold standard tests for the detection of TB in children Dr Siva Kumar, a senior scientist at NIRT said."Most children are missed in diagnosis because of these challenges.
Presently, gastric juice is the choice of sample for the detection of TB in the paediatric population. This process is also difficult as it involves inserting a tube into the stomach for collecting gastric juice," Dr Kumar said.
"Usually, paediatric patients swallow their sputum and this comes out through the stool. Thus stool testing can be used for detection of pulmonary tuberculosis," he said. To close the diagnostic gap, he said NIRT has developed a methodology for the extraction of DNA from stool samples for the diagnosis of tuberculosis in paediatric patients.
Now, this method is under validation in the laboratory and will undergo multicentric studies before being used in the field, Dr Kumar added.India has pledged to end TB by 2025, five years ahead of the global Sustainable Development Goals (SDG) target of 2030.
- wellnessCentury-Old TB Vaccine Could Be Effective Against Covid-19 And Other Infections: New Study
- wellnessTB Patients At Increased Risk Of All-Cause Mortality Even After Treatment: ICMR
- wellnessGovt To Launch Programme For Adopting, Providing Nutritional, Treatment Support To TB Patients
- wellnessSerum Institute Seeks Emergency Use Authorisation For Its rBCG Tuberculosis Vaccine
- wellnessWorld TB Day 2022: How Does Tuberculosis Affect Fertility? (Expert Article)
- babyWorld TB Day 2022: Tuberculosis In Babies And Children, Its Stages, Symptoms And Can It Be Prevented?
- disorders cureWorld TB Day 2022: FAQs On Tuberculosis Treatment And Its Link To COVID-19
- nutritionWorld TB Day 2022: Foods To Consume And Avoid By Tuberculosis Patients
- disorders cureWorld TB Day: Expert Article On Tuberculosis And Ayurveda
- disorders cureWorld TB Day: More Than 40% Of Indian Population Carry Tuberculosis Infection But Only 10% Get The Disease
- healthFujifilm India Launches 'Never Stop: Screening to Reduce Diagnostic Delays' Campaign On Tuberculosis
- disorders cureCOVID-19 And Tuberculosis: Can TB Increase COVID Risk?