Just In
- 1 hr ago Aditi Rao Hydari's Double Diamond Engagement Ring Is Unique, Celebrity Wedding Rings That Are Bookmark Worthy!
- 5 hrs ago Navratri 2024 Date In April: When Will Chaitra Navratri Festival Start? Significance Of 9 Days, Deets Inside!
- 5 hrs ago Ramadan 2024: 6 Bollywood-Inspired Outfit Ideas To Shine During The Holy Month
- 7 hrs ago Personality Traits Of April Born Babies: From Being Witty, To Charismatic And More, They Are Full Of Sheer Joy
Don't Miss
- News Rs 10 Lakh Reward Offered For Information On Rameshwaram Cafe Blast Suspects
- Finance 3 Bonus Issues: Tata Group IT Giant To Recommend Dividend In 14 Days, Buy?
- Sports RCB vs KKR: Why was Shreyas Iyer confused to name his Team during Toss?
- Movies MasterChef Tamil, Telugu OTT Release Date, Platform, Contestants Name- All You Need To Know
- Automobiles Citroen Basalt Vs Tata Curvv – The Beauty Contest
- Travel Choosing Your Next Home: Hyderabad Or Pune?
- Education National Management College begins admissions for CA and CMA courses
- Technology Samsung Galaxy M15 5G Launch in India Teased; Could Be Priced Under Rs 15,000
Blood Clot Disorders That Are Genetic
Blood clot disorders that are inherited and present at birth could create problems throughout your life. When you sustain an injury, components of the blood such as platelets and plasma help in stopping the blood loss from the cut. This happens by thickening the blood and making it form a clot. However, if there is too much blood clotting, it leads to a hypercoagulable state. This is what is referred to as an abnormal clotting condition.
Inherited Blood Clotting Disorders
Several studies have been conducted in identifying the role of genetics in causing blood clotting disorders. As more knowledge is acquired about genetics, these disorders can be better understood and differentiated from each other.
The most commonly occurring inherited clotting disorders are Factor V Leiden and prothrombin gene mutation. The less common ones are antithrombin and protein S and protein C deficiencies.
Read on to know more about these inherited blood clotting disorders.
Prothrombin Gene Mutation
This blood clotting disorder involves a genetic defect which causes overabundance of a blood clotting protein known as prothrombin, also called Factor II. This disorder usually causes clots in the veins.
Children with this disorder have at least one gene that is affected. It is quite uncommon for a child to have both the genes affected by this.
Prothrombin is essential for normal clotting of blood and to stop bleeding in case of cuts. Children who have this disorder, tend to have too much of prothrombin that makes their body to produce more number of blood clots than required.
A person's chances of forming more clots increase when he or she has contracted a serious medical condition or has an undiagnosed autoimmune disease. The risk also increases when one is on birth control (such as oral contraceptives).
Most Read : Top 12 Foods That Are Rich In Folate
• Antithrombin Deficiency
A natural protein, antithrombin helps in the prevention of blood clots. Deficiency of this in the body can cause blood clots in an abnormal way. The occurrence of this disorder is dependent on how much of this natural protein a person has.
When a child is diagnosed with this disorder, he would be treated in the following ways:
- Through blood thinners: These are sufficient to treat and prevent occurrence of abnormal blood clots.
- Through antithrombin-containing factors - this can be either synthetic (in man-made form) or blood-derived
However, this disorder is quite uncommon (found in less than 1 per cent of the population).
• Factor V Leiden
This is the most common blood clotting disorder. Most of the people with this condition have one normal gene and one affected gene. Rarely a child has both the genes affected.
Factor V, a protein, helps in the clotting of blood. When this disorder is present, a child's body is unable to turn this factor V off resulting in too much blood clotting. When a child has one affected gene, the chances of having blood clots almost increase by 10 times.
However, studies have shown that usually a child with this disorder does not get a clot during the childhood years or even during adulthood. The chances of having blood clots increase once there is some serious illness or an undiagnosed autoimmune disease.
Use of birth control pills also increases the effects of having blood clots in an abnormal way due to the presence of this disorder.
Most Read : 10 Dangerous Habits That Can Cause Cancer
Protein C and Protein S Deficiency
This
is
quite
an
uncommon
form
of
blood
clotting
disorder
(found
roughly
in
less
than
1
per
cent
of
the
population).
Clinical
symptoms
usually
begin
to
develop
during
early
adulthood.
The
person
remains
at
the
risk
of
having
abnormal
blood
clots
throughout
his
life.
Protein
C
and
protein
S
are
meant
to
work
together
in
one's
body
to
prevent
the
occurrence
of
blood
clots.
Not
having
enough
of
either
protein
can
lead
to
this
disorder.
When
protein
C
or
protein
S
deficiency
is
inherited,
the
chances
of
getting
a
blood
clot
increase
about
10
to
20
times.
The
condition
usually
begins
to
show
effect
only
after
one
has
crossed
his
or
her
teen
years.
- Protein C deficiency
- Protein S deficiency
This affects almost people of all races. Inherited form of this disorder is found to affect one in 1000 people. Treatment of this deficiency is with the use of a plasma-derived protein C concentrate. This replaces the missing protein in the body.
This affects all races. It is found to occur in one out of about 5000 people. Patients suffering from this order are usually treated with plasma or blood thinners.
Although, severe deficiency of protein C and S is rare, it still could occur. Babies who are born with severe forms of this condition are found to have blood clots during birth that can cause blindness and brain damage. This condition can be immediately diagnosed post birth, as the baby is born with purple-coloured patches on the skin. These patches are blood clots under the skin.
- healthDry Ice Served Mistakenly As Mouth Freshener At Gurgaon Cafe, Know Effects Of Dry Ice If Ingested
- insyncWhy Did Mongol Warriors Drink Blood? How Did It Play Crucial Role In Military Expeditions?
- wellnessWorld Diabetes Day 2023: Avoid These Common Mistakes When Testing Blood Sugar Levels
- pregnancy parenting14 Children Infected With HIV, Hepatitis After Blood Transfusion In UP Hospital: How Did It Happen?
- wellnessDid You Know Your Own Blood Can Be Used For Pain Relief?
- healthWorld Blood Donor Day 2023: People Who Shouldn't Donate Blood
- healthWorld Thalassemia Day 2023: Expert On Alpha Thalassemia; What Lifestyle Changes Should One Adopt?
- wellnessWHO Urges Eligible People To Make Regular, Voluntary, Unpaid Blood Donations
- disorders cureCOVID-19 And Blood Thinners: How Do They Help Increase Survival Rates In Critical COVID-19 Patients?
- wellnessAre There Home Remedies For Blood In Stool?
- wellnessDo You Donate Blood? Here Are The Benefits And Risks Of Blood Donation
- wellnessWhat Are Blood Thinners? Read About 8 Natural Blood Thinning Foods