Just In
- 8 min ago
Hair Dyes Can Increase The Risk Of These 6 Diseases
- 24 min ago
Jacqueline Fernandez, Nushrat Bharucha Give Us Winter-perfect And Summer-ideal Airport Attire Goals
- 28 min ago
7 Ways To End A Dry Spell In Your Relationship And Have A Healthy Sex life
- 1 hr ago
Instagram Beauty Trends Of The Week: Kim Kardashian, Rita Ora, Disha Patani & More
Don't Miss
- News
FIR against 4 rape accused killed in encounter in Hyderabad for 'attacking' cops
- Finance
Donald Trump Calls For World Bank To Stop Lending To China
- Sports
Cricket Australia promise 'international standard' wicket for Boxing Day Test
- Movies
Arjun Suravaram Box Office Verdict: Nikhil Siddharth Starrer Emerges As A Hit!
- Technology
OnePlus 8 Lite Design Revealed Via CAD-Based Renders
- Education
TOEFL Go! Global: A Mobile App From ETS To Stand Out In Exam
- Automobiles
Husqvarna Svartpilen 250 & Vitpilen 250 Revealed At India Bike Week 2019
- Travel
A Brief Travel Guide For Solo Travellers To Conquer South India
Vitamin Therapy May Prevent Deadly Skin Cancer: Study
A therapy using a form of Vitamin B3 can potentially prevent melanoma - a deadly skin cancer - according to scientists, including one of Indian origin. Researchers from University of Sydney in Australia found that nicotinamide can help reduce or reverse DNA damage, inflammation, and immunosuppression caused by ultraviolet radiation.
The cost of nicotinatimide is about USD 10 per month if taken at one gramme per day as recommended, researchers said. Randomised placebo controlled trials are now warranted to determine its efficacy and safety for melanoma prevention, they said. Ultraviolet radiation (UVR) causes DNA damage in melanocytes by producing photolesions such as cyclobutane pyrimidine dimers and 8-oxo-7-hydrodeoxyguanosine.
The production of reactive oxygen species by UVR also induces inflammatory cytokines that, together with the inherent immunosuppressive properties of UVR, propagate carcinogenesis, researchers said. Nicotinamide (Vitamin B3) enhances DNA repair, modulates the inflammatory environment produced by UVR, and reduces UV- induced immunosuppression.
As nicotinamide reduces the incidence of actinic keratoses and nonmelanoma skin cancers in high-risk individuals and enhances repair of DNA damage in melanocytes, it is a promising agent for the chemoprevention of melanoma in high-risk populations.
"Nicotinamide has been show in a clinical trial - called ONTRAC - to reduce the incidence of non-melanoma skin cancer in high-risk individuals and it would be worthwhile to determine whether it would also be useful for high-risk melanoma patients," said Gary Halliday from University of Sydney. The study was published in the Photodermatology, Photoimmunology and Photomedicine.