Scientists Discover New Mechanism To Slow Progress Of Neurodegenerative Diseases

Scientists in the UK have discovered a new mechanism that could help slow down the progression of neurodegenerative diseases like dementia and neurological decline associated with ageing, according to a research published on Wednesday.

The research was conducted by UK's University of Sheffield scientists. The Scientists identified that tuning up the activity pathway of the DNA's natural repair toolkit that normally helps to restore breakages in genetic material could help to prevent the death of nerve cells which trigger neurological diseases.

The scientists examined the C9 or f72 gene, which contains six DNA nucleotides - the building blocks of DNA where all-important cellular information is stored.

When this series of nucleotides is expanded and repeated multiple times, neurodegenerative diseases can occur. The expansions of the gene forms genetic material called 'R-loops' which make the DNA vulnerable to breakages.

They found that accumulation of R-loops and increased DNA breakage in neurons lead to neurodegenerative diseases.

Human cells have their own repair toolkits specially designed to fix breaks in DNA, however, the products of the expansion over-activate a process called autophagy - a process that gets rid of misfolded or "unwanted" proteins.

The new study, jointly directed by Professor Sherif El- Khamisy and Professor Mimoun Azzouz, published in Nature Neuroscience, shows that the expansion driven over-activation of this process can degrade some of the very precious DNA toolkits, meaning the cells will eventually die.

"We were able to shut down the out-of-control degradation process, which runs down the cell's ability to fix genomic breaks, using genetic techniques. Even though the DNA was still damaged, the cells were able to cope and did not die" said El-Khamisy.

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