For Quick Alerts
For Daily Alerts

Know How Prolonged Antacid Use Can Increase Stomach Cancer Risk

By Staff

Taking a medicine to get rid of any health issue is considered normal, but there are certian medicine, which if used for a long period of time can cause certain side-effects.

A new study has found that long-term intake of drugs commonly used to treat acid reflux conditions such as heartburn and ulcers may double the risk of developing stomach cancer.

The risk associated with the use of proton pump inhibitors (PPIs) rose in tandem with the dose and duration of treatment following elimination of Helicobacter pylori, the bacteria implicated in the development of stomach cancer, said researchers from The University of Hong Kong.

Eliminating H pylori from the gut significantly lowers a person's risk of developing stomach cancer. However, a substantial proportion of those in whom treatment is successful still go on to develop the disease, the third leading cause of cancer death in the world.

Previous research has found an association between PPI use and heightened stomach cancer risk, but it was unable to factor in the potential role of H pylori itself, so undermining the strength of the findings.

For the study, researchers compared the use of PPIs with another type of drug used to dampen down acid production called histamine H2 receptor antagonists (H2 blockers) in 63,397 adults treated with triple therapy - a combination of a PPI and two antibiotics to kill off H pylori over seven days.

They were subsequently monitored until they either developed stomach cancer, died, or the study ended, whichever came first. The average monitoring period lasted 7.5 years. During this time, 3,271 (5 per cent) people took PPIs for an average of nearly three years; and 21,729 took H2 blockers. In all, 153 (0.24 per cent) people developed stomach cancer after triple therapy.

None tested positive for H pylori at the time, but all had long standing gastritis (inflammation of the stomach lining). Taking PPIs was associated with a more than doubling (2.44) in the risk of developing stomach cancer, while taking H2 blockers was not associated with any such heightened risk.

The average time between triple therapy and the development of stomach cancer was just under five years.

More frequent use was associated with greater risk, with daily use linked to a more than quadrupling in risk (4.55) compared with weekly use, researchers said. The longer PPIs were used, the greater was the risk of developing stomach cancer, rising to five-fold after more than a year, to more than six-fold after two or more years, and to more than eight-fold after three or more years.

"This is an observational study, so no firm conclusions can be drawn about cause and effect, and PPIs are generally considered safe," the researchers said. However, recent research has linked their long term use to various unwanted effects, including pneumonia, heart attack, and bone fracture. PPIs are known to stimulate the production of gastrin, a powerful growth factor, researchers said.

The study was recently published in the journal Gut.

Meanwhile, also learn about the other risk factor for cancer. Take a look.


1. Tobacco Use:

Tobacco use in any form is one of the most common cause for cancer. Despite knowing the fact that tobacco consumption is harmful for your health, many people fail to quit the habit. Cancer of the larynx, mouth, esophagus, bladder, kidney, throat, stomach, pancreas and cervix are the major form of cancer that tobacco use can cause.


2. Alcohol Abuse:

Alcohol use in limited quantity occasionally can be helpful for your health but alcohol abuse can lead to several health problems and cancer is just one of the major one. Cancers of the mouth, throat, esophagus, larynx, liver and breast are the major ones caused by alcohol abuse.


3. Poor Diet:

A healthy diet is very essential to ward off cancer. Several studies have pointed out that having a poor diet, lack of exercises and physical activity can increase the risk of cancer. Cancer related to breast, colon, esophagus, kidney, and uterus are the major ones caused due to poor diet.


4. Family History:

Cancer can also be passed on from the genes. Cancers generally develop because of changes (mutations) in genes. Certain gene changes that increase the risk of cancer are passed from parent to child. These changes are present at birth in all cells of the body.

(With Agency Inputs)

Read more about: medicine stomach cancer
Story first published: Thursday, November 2, 2017, 23:00 [IST]
We use cookies to ensure that we give you the best experience on our website. This includes cookies from third party social media websites and ad networks. Such third party cookies may track your use on Boldsky sites for better rendering. Our partners use cookies to ensure we show you advertising that is relevant to you. If you continue without changing your settings, we'll assume that you are happy to receive all cookies on Boldsky website. However, you can change your cookie settings at any time. Learn more