Just In
- 2 hrs ago Russian Influencer Starves His Newborn To Death With Sunlight Diet, Know Dos And Don’ts Of This Diet
- 4 hrs ago Mahavir Jayanti 2024: Date, Time, History, Celebrations And Teachings Of Lord Mahavir In Jainism
- 5 hrs ago Parineeti Chopra Saree Looks: Check Amar Singh Chamkila Actor's Regal Fashion Statements
- 7 hrs ago Vidya Balan's 'Do Aur Do Pyaar' Urban Boho Style Avatar Is Relatable And Inspiring, Check Her Modern Avatar!
Don't Miss
- Sports IPL 2024: CSK coach Stephen Fleming talks about space 'owned' by MS Dhoni, calls 42-year-old heartbeat of team
- Finance Elon Musk Postpones India Trip, Tesla's Indian Market Entry Delayed
- News US Links 'Blue Whale Challenge' To Indian Student's Death In Boston | What Is The 'Suicide Game'?
- Movies Love, Sex Aur Dhokha 2: The REAL Reason Of Rajkummar Rao And Nushrratt Bharuccha Not Being Part Of The Film
- Technology Best Noise-Cancelling Earbuds Under Rs 5,000: CMF Buds Pro, Redmi Buds 5, Realme Buds Air 5, and More
- Education UPMSP Class 10 and 12 Results 2024 Released Today, Check the Details Here
- Automobiles Tesla CEO Elon Musk's Much-Awaited Visit to India Deferred, Leaving Questions Unanswered
- Travel Journey From Delhi To Ooty: Top Transport Options And Attractions
This One Natural Ingredient Helps Treat Bowel Cancer Effectively
A new study has found that probiotics may help prevent and treat bowel cancer.
Alteration of the gut microbiome with probiotics may help prevent and treat bowel cancer by reducing inflammation and suppressing colon tumours, a study in mice suggests.
Researchers at Baylor College of Medicine, Texas Children's Hospital and Columbia University in the US found that administration of histamine-generating gut microbes reduced inflammation and tumour formation in mice which lacked that ability to produce histamine on their own.
These results suggest that alteration of the gut microbiome with probiotics may become a new preventative or therapeutic strategy for patients at risk for colorectal cancer associated with inflammatory bowel disease.
"We are on the cusp of harnessing advances in microbiome science - the study of the microbes living in our body - that would facilitate diagnosis and treatment of human disease," said James Versalovic, Professor at Baylor College of Medicine.
"By simply applying diet-based cancer prevention strategies, such as supplementing microbes that provide missing life substances, we can potentially reduce the risk of cancer," said Versalovic.
Previous studies had shown that histamine, a chemical produced by the body that is well-known for its role in allergic disease, also may have a potential anti-tumour effect.
In the new study, researchers investigated whether the probiotic L reuteri 6475, which is able to generate histamine, had the ability to reduce the frequency and severity of inflammation-associated colorectal cancer in mice that were not able to produce histamine on their own.
The researchers conducted a series of experiments using mice that were deficient in histidine decarboxylase, the enzyme required to convert L-histidine to histamine.
Experimental mice were orally administered L reuteri 6475, which has the gene for histidine decarboxylase to produce histamine; control animals received L reuteri that lacked the gene to produce histidine decarboxylase.
The probiotic was administered both before and after the mice received a single treatment to induce tumour formation. Fifteen weeks later, the mice were sacrificed and the tissues removed for study.
The animals treated with L reuteri 6475 showed increased expression of bacterial histidine decarboxylase enzyme and of the amount of histamine in their colons. Positron emission tomography (PET) used to visualise the tumours showed that these mice had fewer and smaller tumours than control mice.
L reuteri strains deficient in histidine decarboxylase activity did not provide protective effects; the mice showed increased numbers of "hot spots" indicative of tumour formation, researchers said.
Treatment with the histamine-generating probiotic also reduced inflammatory responses typically associated with increased risk of tumour development.
"These observations are consistent with the conclusion that histamine-generating probiotic L reuteri may attenuate development of colorectal cancer in the animal model, at least in part, via reduction of a pro-cancer inflammatory response," said Versalovic.
- healthExclusive: Cervical Cancer In India, Doctor Shares Preacautions And Treatments That One Needs To Be Aware Of
- healthTV Actor Dolly Sohi Passes Away Due To Cervical Cancer, Know The Early Signs That Are Beyond Early Detection
- healthGhazal Maestro Pankaj Udhas Passes Away Due To Pancreatic Cancer, Know Risk Factors, Prevention, Treatments
- healthNew Study Finds Links Infertility In Men With Increased Risk Of Cancer For Them And Their Relatives
- healthIs Pancreatic Cancer Curable? Know The Causes, Warning Signs, And Treatment Of This Uncommon Silent Killer
- insyncBaba Vanga's Prophecy For 2024 May Come True With New Vaccine In Russia For Cancer
- healthDetecting Bowel Cancer: 10 Signs Of This Silent Killer To Watch Out For And Seek Medical Attention
- health10 Cancer Fighting Foods That Help That Play Significant Role In Supporting Body's Natural Defences
- healthWorld Cancer Day 2024: 5 Simple Daily Habits To Reduce The Risk Of Developing Cancer
- healthWorld Cancer Day 2024: Messages, Greetings, Wishes, Texts, Images, FB And WhatsApp Status
- healthExclusive: Poonam Pandey Didn't Die Of Cancer, However, It Does Spark Urgency For Cervical Cancer Awareness
- healthErotica Star Poonam Pandey 'Dead From Cervical Cancer' Stunt: Causes, Symptoms, Treatment Of Cervical Cancer