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New Way To Improve Chemotherapy In Cancer Patients
Here is a way to improve chemotherapy in cancer patients, check it out.
Chemotherapy is a painful procedure and comes with certain side-effects as well. Taking care of the diet and the food that you eat plays a very important role for those undergoing chemotherapy.
But a new research has come out with some good news for those undergoing chemotherapy. Researchers at Washington University School of Medicine have found that human cells have a way of detecting and mending DNA damage caused by some common chemotherapy drugs and to knock out this mending function may increase the potency of certain chemotherapy drugs in treatment of cancer.
Some of the oldest chemotherapy drugs known as alkylating agents kill cancer cells by adding groups of carbon and hydrogen atoms to or alkylating DNA.
"We found that human cells can sense alkylation damage and mobilize a repair complex specifically suited to repair this kind of injury," said senior author Nima Mosammaparast, an assistant professor of pathology and immunology at Washington University School of Medicine.
Alkylation can happen naturally, which is why cells have this repair system in the first place. Certain chemotherapy drugs also force it to happen.
Studying cells treated with alkylating chemotherapy drugs or with drugs that lead to other kinds of DNA damage, the researchers have determined how cells try to mend DNA damage caused specifically by alkylating agents.
They identified a group of proteins that clustered near the spots on the DNA that had been alkylated. When treated with alkylating drugs, cells lacking a key member of this protein complex were more likely to die than cells having the protein.
These findings suggest that sensing alkylation damage is a major primary defense against chemotherapy drugs and other alkylating agents.
Interfering with this repair complex could amplify the killing power of such drugs and potentially even avert or undermine drug resistance.
Tumors that have high levels of key alkylation repair proteins are often dependent on them. If those proteins were somehow inhibited, the cells would die.
"That could be an opening for a chemotherapy drug," Mosammaparast said. "We may be able to design a drug that is toxic to tumors but not to normal cells by targeting this alkylation repair pathway."
The findings have been recently published in the journal Nature.
Here is a list of foods that are good for cancer patients. Check them out.
1.
Whole
Grains:
Chemotherapy
can
have
serious
impact
on
the
patient.
Hence
making
healthy
choice
of
foods
is
important.
Including
foods
rich
in
fibre
is
essential
as
this
helps
in
better
digestion
and
at
the
same
time
helps
in
keeping
one
full
for
a
longer
period
of
time.
2.
Fruits
&
Vegetables:
Fruits
and
vegetables,
especially
green
vegetables
are
rich
in
all
the
essential
nutrients.
Leafy
green
vegetables
are
rich
in
vitamins,
minerals,
antioxidants
and
enzymes
and
low
in
calories,
fats,
sodium.
Adding
green
vegetables
and
fruits
on
a
regular
basis
helps
in
fighting
cancer
effectively.
3.
Nuts:
Rich
in
good
fats,
fibre
and
other
essential
minerals,
nuts
especially
almonds,
walnuts
and
brazil
nuts
are
a
must
have
for
cancer
patients.
(With Agency Inputs)
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