- 9 hrs ago Delta Still Dominant Strain Of COVID-19, Says Maharashtra Health Official Amid Omicron Scare
- 9 hrs ago Mithali Raj And Indian Women's Cricket Team To Quarantine In Mumbai Ahead Of Women's World Cup 2022 Departure
- 10 hrs ago Tennis Legend Chris Evert Reveals She Has Ovarian Cancer And Is Undergoing Treatment
- 21 hrs ago Republic Day Celebrations To Begin From Netaji Subhas Chandra Bose Birth Anniversary On January 23 Every Year
- News Legendary Kathak dancer Birju Maharaj passes away
- Technology Amazon Great Republic Day Sale 2022: Discounts On Premium Smartphones Revealed
- Movies Bangarraju Day 3 Box Office Collection: Naga Chaitanya-Nagarjuna’s Film Is Unstoppable!
- Finance 5 Stocks That Jumped 46% To 65% In 7-Days, Should You Buy?
- Sports Rohit Sharma shocked over Virat Kohli's decision, congratulates him on a successful stint as India captain
- Education BSEB Inter Admit Card 2022 Released, Check Steps And Links To Download BSEB Bihar Intermediate Admit Card Here
- Automobiles Skoda Slavia Vs Skoda Kushaq: Which One Is The Right 5-Seater Car For You?
- Travel Amazing Places To Visit In West Bengal In Winter Of 2022
Scientists, including an Indian-American researcher, have identified a molecule that can help treat breast cancer, giving hope to patients who have become resistant to traditional therapies. The first-in-class molecule shuts down oestrogen-sensitive breast cancer in a new way, researchers said. First-in-class drugs are those that work by a unique mechanism - in this case, a molecule that targets a protein on the oestrogen receptor of tumour cells.
The potential drug offers hope for patients whose breast cancer has become resistant to traditional therapies.
"This is a fundamentally different, new class of agents for oestrogen-receptor-positive breast cancer," said Ganesh Raj, professor at the University of Texas Southwestern (UT Southwestern) Simmons Cancer Center.
"Its unique mechanism of action overcomes the limitations of current therapies," Raj said.
All breast cancers are tested to determine if they require oestrogen to grow and about 80 per cent are found to be oestrogen-sensitive, researchers said. These cancers can often be effectively treated with hormone therapy, such as tamoxifen, but as many as a thirds of these cancers eventually become resistant, they said.
The new compound is a potential highly effective, next-line treatment for these patients, said Raj.
Traditional hormonal drugs, such as tamoxifen, work by attaching to a molecule called the oestrogen receptor in cancer cells, preventing oestrogen from binding to the receptor, a necessary step for cancer cells to multiply.
However, the oestrogen receptor can mutate and change its shape over time so that the treatment drug no longer fits neatly with the receptor. When this happens, the cancer cells start multiplying again.
"There has been intense interest in developing drugs that block the ability of the oestrogen receptor - the prime target in most breast cancers - from interacting with the co-regulator proteins that cause a tumour's growth," said David Mangelsdorf, professor at UT Southwestern.
"Blocking such "protein-protein interactions" has been a dream of cancer researchers for decades.
The drug works by blocking other molecules - proteins called co-factors - that also must attach to the oestrogen receptor for cancer cells to multiply. The new molecule, dubbed ERX-11, mimics a peptide, or protein building block.
- disorders cureExpert Article: Breast Conservation Surgery - The New Paradigm
- healthHCG Cancer Hospital Conducts Free Breast Cancer Screening Camp & Awareness Talk For KSRTC Women
- healthBreast Cancer Awareness Month 2021: Tahira Kashyap Khurrana Gives A Reminder Of Self-love
- disorders cureExpert Article: Breast Cancer Early Detection, Screening, And Management
- wellnessWhy Women Should Include Mangoes In Their Diet - 10 Evidence-Based Reasons
- disorders cureThis COVID-19 Vaccine Side Effect Could Be Confused With A Breast Cancer Symptom, Says Study
- wellness11 Progesterone-Boosting Foods That Can Increase The Hormone Naturally
- wellnessRose Day (Welfare of Cancer patients): What Should You Not Eat When You Have Cancer?
- health‘One note, one donation’ Campaign: Exclusive Song To Support Breast Cancer Research
- disorders cureWorld Cancer Day: COVID-19 And Breast Cancer
- wellnessWomen's Health: 12 Important Health Tests Every Woman Should Take
- wellnessBreast Cancer Awareness Month 2020: Effective Devices To Diagnose Breast Cancer In Women