As body mass index (BMI) increases, so does the growth and spread of the blood cancer multiple myeloma, which accounts for about 10 per cent of all the blood cancers in patients, a study warns.
"Once a person with cancer is out of the normal weight category, their BMI is contributing to multiple myeloma growth and progression," said the lead study author Katie DeCicco-Skinner, Associate Professor of Biology at the American University.
Obesity is believed to be a risk factor for many cancers.
In the multiple myeloma study, normal weight is defined as a BMI of not more than 25 kilograms per metre squared, and morbidly obese is in the range of 35 to 40 kilograms per metre squared.
The researchers examined the BMI of normal, overweight, obese and morbidly obese patients, and the effects on multiple myeloma.
They obtained stem cells from the discarded fat of liposuction patients who underwent elective surgery.
They turned them into fat cells and cultured the fat cells with multiple myeloma.
The researchers found that as a patient's BMI increased, fat cells communicated with multiple myeloma cells.
Fat cells grow larger, gain additional lipid and secrete proteins linked to cancer, the findings showed.
The researchers also found a correlation between BMI and angiogenesis and adhesion, which are the key indicators of progression.
The study was published in the journal Cancer Letters.
"We found that fat cells from obese or morbidly obese patients
secreted a high amount of inflammatory proteins, which contributed
to tumour progression," DeCicco-Skinner concluded.
Inputs from IANS