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Hypopituitarism – Hormonal Disorder
Hypopituitarism otherwise called as pituitary insufficiency refers to the low levels of circulating pituitary hormones. The clinical features of hypopituitarism are those of pituitary hormonal defeciency
What causes hypopituitarism?
1.Pituitary
tumors
2.Radiotherapy
3.Inflammation
called
Hypophysitis
4.Invasion
of
the
gland
(
Sarcoidosis,
haemochromatosis)
5.Empty
sella
syndrome
What are the necessary investigations?
1.Baseline
hormone
levels
-
Both
basal
concentrations
of
the
pituitary
hormones
and
the,
target
hormone
levels
are
to
be
measured,
as
it
may
remain
within
the
target
range
despite
low
target
hormone
levels.
1.LH,
FSH,
Oestradiol,
Testosterone
2.TSH
and
free
T4
3.8
am
cortisol
4.Prolactin
2.Dynamic testing
1.Insulin
tolerance
test
2.Short
synacthen
test
3.hCG
stimulation
test
4.Clonodine
test.
What is the treatment?
1.Adequate and appropriate replacement of the deficient pituitary hormones - At present we can replace all the hormones and quality of life can be put back to normal
2.Treatment of the cause
3.Hypopituitarism is usually permanent and requires life-long treatment & monitoring.
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