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Study Links Obesity, T2DM, And Neurodegeneration
A new study has found that obesity and Type 2 Diabetes Mellitus (T2DM) can contribute to mild neurodegeneration with features common with Alzheimer's disease (AD).
Researchers at Rhode Island Hospital say their study is the first one to show that obesity can cause neurodegeneration.
In a study on animal models, lead author Suzanne de la Monte, MD, MPH, of Rhode Island Hospital, utilized chronic high fat diets to cause a two-fold increase in mean body weight.
In
these
models,
there
was
a
marginally
reduced
mean
brain
weight
and
a
significantly
reduced
mean
brain
weight/body
weight
ratio,
providing
evidence
that
obesity
with
T2DM
is
sufficient
to
cause
mild
global
atrophy
in
the
brain.
"In essence, the brain shrinks and several biochemical and molecular abnormalities found in patients with AD, including brain insulin resistance, develop with chronic obesity and T2DM. However, the extent of the abnormalities in no way matches AD."
It is found that the neuropathological abnormalities were mild and the associated brain insulin resistance could serve as a co-factor in the development and progression of AD.
Overall, the study showed that that the effects of obesity and T2DM can essentially aggravate or contribute to the severity or progression of AD, but cannot be the sole cause of the condition.
The findings suggest that strategies to reduce obesity and prevent or control T2DM could modify the clinical course of mild cognitive impairment and AD.
"We don't know yet if these effects of T2DM/obesity are reversible with weight loss. However, we're fairly sure that the abnormalities are related to the T2DM that accompanies obesity and not just increased weight," De la Monte said.
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